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Even in ancient times people are unaware with the existence of living organisms invisible to essay stone com the eye, causing illness. Thus, the ancient Greek scientist and physician Hippocrates expressed this assumption in one of his works. But come to grips with their study of mankind has been capable only following the Dutch optician van Leeuwenhoek inside the XVI century made the initial microscope and saw firsthand the bacteria within a drop of water. Then again, many within the class scientist denied the existence of pathogens within a handful of centuries following the invention of Leeuwenhoek.